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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0or more subsequent prednisolone treatments. It has been demonstrated that in patients with chronic rheumatoid arthritis, chronic steroid therapies may increase the risk of developing osteoarthritis and other complications in the early, middle, or late term of disease . In clinical settings, prolonged use of prednisolone in the treatment of osteoarthritis could potentially increase the risk for joint pain and joint disorders and other disorders. Thus, the need exists to determine the safety of these steroid therapies in patients with osteoarthritis. In addition to the osteoarthritis-related outcomes associated with prednisolone, an increasing body of evidence is finding that there are adverse effects of glucosamine in patients with osteoarthritis , and that treatment with glucosamine has a low benefit for pain . However, patients with chronic rheumatoid arthritis who are taking glucosamine have a lower incidence of disability and the majority of these patients would not likely be at risk for osteoarthritis or osteoporosis or other adverse long-term consequences associated with glucosamine therapy. Overall, evidence from clinical and in vitro studies suggests that glucosamine administration in patients with osteoarthritis is safe, but further examination by the US Food and Drug Administration is needed to address the potential consequences of oral glucosamine on patients with osteoarthritis. Despite the current evidence based on the evidence based on the preclinical data and on in vitro data provided by these studies, it appears that prednisolone, like the other steroids that are commonly used for the treatment of osteoarthritis, needs to be studied more thoroughly to determine the long-term safety of glucosamine therapy as well as the implications of these drugs for the management of osteoarthritis and other common joint diseases. This is especially true if glucosamine is prescribed to children and youth as the other steroids. Author Contributions H.R. and E.M.G. designed the research; H.R., P.C., and H.E. performed the experiments; H.R., P.C., and H.E. analyzed the data; and H.E., H.R.R., P.C., and E.M.G. wrote the paper. Funding/Support This work was supported by grant 5 R01 HD04904: Fundamentals and Management of Chronic Rheumatic Diseases. Similar articles: